Relationship Between Endoplasmic Reticulum Stress and Pain in Patients With Endometriosis

Kanuni Sultan Suleyman Training and Research Hospital86 enrolled

Overview

The correlation between painful symptoms (dysmenorrhea, dysparonia, dysuria, chronic pelvic pain) symptoms and endoplasmic reticulum stress was investigated in 86 patients diagnosed with endometriosis. For this, xbp-1 (x box binding protein-1) level was measured in patients. XBP-1 is an endoplasmic reticulum stress indicator and is known to be involved in pain pathogenesis.

Women between the ages of 18-50 who were diagnosed with endometriosis by surgery and ultrasound, without known rheumatological or metabolic diseases were included in the study. Most of the patients are composed of newly diagnosed patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Endometriosis Endoplasmic Reticulum Stress Endometriosis-related Pain

Interventions

xbp-1 - endometriosis patients groupOTHER

Patients diagnosed with endometriosis by surgery and ultrasound and whose xbp-1 level was examined

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * diagnosed endometriosis with ultrasound or surgery * no metabolic diseases * no rheumatological diseases Exclusion Criteria: * Immune modulator, hormonal, anti-inflammatory use history in the last 3 months

Locations (1)

Pinar Yalcin Bahat

Istanbul, İ̇stanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Evaluation of the correlations between the results of XBP-1 levels and the stages and pain symptoms of endometriosis.

Time frame: 5 months

Secondary Outcomes

serum XBP-1levels in patients wit endometriosis

Time frame: 5 months

Data from ClinicalTrials.gov

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