Research Study to Assess New Chikungunya and Zika Vaccines in Healthy Adults in Mexico.

Inclusion Criteria: 1. Healthy men aged 18 to 50 (inclusive) years at the time of screening. 2. Healthy women aged 18 to 50 (inclusive) of child-bearing potential who agree to practice continuous effective contraception (see below) during the study and test negative for pregnancy on the day(s) of screening and vaccination. 3. Are residents of the metropolitan area of Monterrey, Nuevo León. 4. Provide written informed consent for participation in the study. 5. Able and willing (in the Investigator's opinion) to comply with all study requirements. 6. Agreement to inform study team of any impending vaccinations either before or during participation in the study. 7. Agreement to refrain from blood donation during the course of the study. 8. Agreement to refrain from receipt of any alphavirus or flavivirus vaccine throughout the duration of the study (e.g. investigational or licensed Yellow Fever, Japanese Encephalitis, Tick Borne Encephalitis or Dengue virus vaccines). Exclusion Criteria: 1. Participation in another clinical trial in the 30 days preceding enrolment or during the study period. 2. Prior receipt of an investigational or licensed vaccine likely to impact on interpretation of the trial data (e.g. Adenovirus vectored vaccine, Chikungunya virus vaccine, Zika virus vaccine, Dengue virus vaccine). 3. Prior receipt of any vaccines administered ≤30 days before enrolment and/or planned during the during the study. 4. Administration of immunoglobulins and/or any blood products within the three months preceding the planned administration of the vaccine candidate. 5. Any confirmed or suspected immunosuppressive or immunodeficient state, including HIV infection; asplenia; recurrent, severe infections and chronic (more than 14 days) immunosuppressant medication within the past 6 months (inhaled and topical steroids are allowed). 6. History of allergic disease or reactions likely to be exacerbated by any component of the vaccine. Any history of anaphylaxis in relation to vaccination. 7. History of autoimmune disease. 8. Any history of hereditary angioedema, acquired angioedema, or idiopathic angioedema. 9. Pregnancy, lactation or willingness/intention to become pregnant during the study. 10. History of cancer (except basal cell carcinoma of the skin and cervical carcinoma in situ). 11. History of serious psychiatric condition likely to affect participation in the study 12. Bleeding disorder (eg. factor deficiency, coagulopathy or platelet disorder), or prior history of significant bleeding or bruising following IM injections or venepuncture. 13. Any other serious chronic illness requiring hospital specialist supervision at present or during the last 6 months. 14. Suspected or known current alcohol abuse. For men, intake greater than 5 drinks on a single occasion or more than 15 drinks per week; and for women, more than 4 drinks on a single occasion or more than 8 drinks per week. One drink =14 grams of pure alcohol. 15. Suspected or known injecting drug abuse in the 5 years preceding enrolment. 16. Seropositive for hepatitis B surface antigen (HBsAg). 17. Seropositive for hepatitis C virus (antibodies to HCV). 18. Any clinically significant abnormal finding on screening biochemistry or haematology blood tests or urinalysis. 19. Has history of chronic or acute severe neurologic condition. Including: Neurologic and Neuroinflammatory Disorders: ADEM, including site specific variants, Cranial Nerve Disorders (including paralyses/paresis), GBS (including Miller Fisher Syndrome and other variants), Immune-mediated Peripheral Neuropathies and Plexopathies, Optic Neuritis, Multiple Sclerosis, Narcolepsy, Transverse Myelitis, meningitis, or meningoencephalitis. 20. Any other significant disease, disorder or finding which may significantly increase the risk to the volunteer because of participation in the study, affect the ability of the volunteer to participate in the study or impair interpretation of the study data. 21. Seropositivity or cross-reactivity to Chikungunya virus, Zika virus or Dengue virus on screening tests.