Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

Saint Alphonsus Regional Medical Center120 enrolled

Overview

Clinicians commonly utilize intraarticular injections to treat symptomatic primary arthritis. Steroid injections are common yet have immune-modulating effects and can alter gene expression which may delay definitive arthroplasty and further damage cartilage. Non-steroidal anti-inflammatory (NSAID) injections may offer a safer profile due to their differing mechanism of action; however, there is a relative dearth of information regarding their efficacy. This non-inferiority study compares the effectiveness of triamcinolone versus ketorolac in treating symptoms of moderate to advanced primary osteoarthritis of the hip and knee.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

120

Conditions

Arthritis Knee Arthritis of Hip

Interventions

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Symptomatic, radiographically proven degenerative joint disease in the hip or knee Exclusion Criteria: * recent injection in the hip or knee within the previous 3 months * history of traumatic osteoarthritis or ligamentous reconstruction * chronic narcotic use * history of inflammatory or neuropathic arthropathy * pregnant and/or nursing women * allergy or strong reaction to study medications

Outcomes

Primary Outcomes

Change in Visual Analogue Scale (Baseline to One Week Post-injection)

Pain Score

Time frame: Comparing baseline to one week post-injection

Change in Visual Analogue Scale (Baseline to One Month Post-injection)

Pain Score

Time frame: Comparing baseline to one month post-injection

Change in Visual Analogue Scale (Baseline to Three Months Post-injection)

Pain Score

Time frame: Comparing baseline to three months post-injection

Change in PROMIS Global Health Scores (Baseline to One Week Post-injection)

Overall patient wellbeing

Time frame: Comparing baseline to one week post-injection

Change in PROMIS Global Health Scores (Baseline to One Month Post-injection)

Overall patient wellbeing

Time frame: Comparing baseline to one month post-injection

Change in PROMIS Global Health Scores (Baseline to Three Months Post-injection)

Overall patient wellbeing

Time frame: Comparing baseline to three months post-injection

Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Week Post-injection)

Functionality and pain of affected knee

Time frame: Comparing baseline to one week post-injection

Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Month Post-injection)

Functionality and pain of affected knee

Time frame: Comparing baseline to one month post-injection

Change in Knee Injury and Osteoarthritis Outcome Score Jr. (Baseline to Three Months Post-injection)

Functionality and pain of affected knee

Time frame: Comparing baseline to three months post-injection

Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Week Post-injection)

Functionality and pain of affected hip

Time frame: Comparing baseline to one week post-injection

Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to One Month Post-injection)

Functionality and pain of affected hip

Time frame: Comparing baseline to one month post-injection

Change in Hip Injury and Osteoarthritis Outcome Score Jr. (Baseline to Three Months Post-injection)

Functionality and pain of affected hip

Time frame: Comparing baseline to three months post-injection

Intraarticular Injections of the Hip and Knee With Triamcinolone Versus Ketorolac: A Randomized Controlled Trial

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes