The purpose of this study is to investigate the absorption, the metabolic pathways and the excretion of ICP-022 in healthy male adult participants after administration of a single oral dose of 150 mg of 14C ICP-022.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
OTHER
Masking
NONE
Enrollment
6
150mg suspension containing 100μCi of \[14C\]ICP-022
The First Affiliated Hospital of Soochow University
Suzhou, Jiangsu, China
Distribution ratio of total radioactivity in whole blood and plasma of [14C]ICP-022
To investigate the pharmacokinetics of total radioactivity in plasma after oral \[14C\] ICP-022 in healthy volunteers, and the distribution ratio of total radioactivity in whole blood and plasma.
Time frame: Up to14 days
Quantitative analysis of total radioactivity in excreta after oral [14C] ICP-022 in healthy volunteers
Quantitative analysis of total radioactivity in excreta after oral \[14C\] ICP-022 in healthy volunteers, obtaining body material balance data and main excretion pathways
Time frame: Up to14 days
Quantitative analysis of the concentration of ICP-022 in plasma
Quantitative analysis of the concentration of ICP-022 in plasma to obtain the pharmacokinetic parameters of ICP-022
Time frame: Up to14 days
The biotransformation pathways of [14C]ICP-022
Urine and fecal collection for metabolite profiling. Identify the main metabolites in humans after oral \[14\]ICP-022 in healthy volunteers to determine the main biotransformation pathways.
Time frame: Up to14 days
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