Post -Extubation Respiratory Failure

Cairo University60 enrolled

Overview

comparing high flow nasal cannula , conventional oxygen tharapy and non invasive ventilation post-extubation period for patients mechanically ventilated due to respiratory failure regarding re-intubation rate, ICU outcome \& 28 days mortality

patients with respiratory failure either type I or type II planned for extubation will be divided into 3 groups post extubation : Group I: will receive high flow nasal cannula giving oxygen 60 litres / minute flow group II: will receive nasal cannula up to 10 litres / minute group III: will receive non invasive ventilation Data of the patients will be collected for 28 days post-extubation and analysed

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

NONE

Enrollment

Conditions

Respiratory Insufficiency

Interventions

High flow nasal cannulaDEVICE

Device gives high flow oxygen comparable to non invasive ventilation and conventional oxygen therapy

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * respiratory failure type I and Type II Exclusion Criteria: * Mechanical ventilation due to other cause such as disturbed conscious level or respiratory muscle weakness

Locations (1)

Faculty of Medicine

Giza, Egypt

Outcomes

Primary Outcomes

Number of participants with post extubation respiratory failure

Number of participants with post extubation hypoxemia with or without hypercapnea

Time frame: 7 days

Secondary Outcomes

Rate of ICU stay and mortality

Duration of ICU stay and incidence of mortality

Time frame: 28 days

Data from ClinicalTrials.gov

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