Total hip replacement (THR) is associated with extensive tissue injury and considerable blood loss that can be complicated by hyperfibrinolysis with an increased need for blood transfusion. THR in patients with cancer involving the hip joint, can reduce pain and improve or maintain the function and quality of life. However, these patients have an increased likelihood of haemostatic abnormalities, such as thrombosis or extensive blood loss. Rotational thromboelastometry is a point-of-care viscoelastic assay that can provide a measure of coagulation disorders in the above settings, and this is still under review. The objective of this prospective cohort study is to quantitate the changes in clot formation dynamics following THR with a subgroup analysis of patients with cancer.
Study Type
OBSERVATIONAL
Enrollment
50
1.8 ml blood sample
I Department of Anesthesiology and Intensive Care Warsaw Medical University
Warsaw, Masovian Voivodeship, Poland
RECRUITINGINTEM parameters change from preoperative to postoperative values
Time frame: 30 minutes before and 30 minutes after surgery
EXTEM parameters change from preoperative to postoperative values
Time frame: 30 minutes before and 30 minutes after surgery
FIBTEM parameter change from preoperative to postoperative values
Time frame: 30 minutes before and 30 minutes after surgery
Total volume of infused fluids
Crystalloids, blood products
Time frame: From first fluid on day of surgery to end of surgery, an average of 12 hours
Pre- and postoperative haemoglobin and haematocrit
Time frame: From day before surgery to postoperative day 3
Intraoperative blood loss
Amount of blood loss in millilitres
Time frame: Blood loss as measured during surgery
Hip Disability and Osteoarthritis Outcome Score (HOOS)
Instrument for measuring outcome following surgery with higher scores representing better function. Score from 0 to 100.
Time frame: The day before surgery and at 6 ± 1 months, 12 ± 1 month after surgery
The 36-Item Short Form Health Survey (SF-36)
Health related Quality of Life measure. Higher score indicates better health state with eight scaled scores each from 0 to 100.
Time frame: The day before surgery and at 6 ± 1 months, 12 ± 1 month after surgery
Visual Analogue Scale (VAS) score
The ends of the scale are defined as the extreme limits of the pain. Orientated from the left (no pain) to the right (worst imaginable pain) measured in millimeters from 0 to 100.
Time frame: The day before surgery and at 6 ± 1 months, 12 ± 1 month after surgery
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