Analgesia After Knee Arthroscopy :Dexmedetomidine vs Fentanyl

Zagazig University45 enrolled

Overview

The aim of this study is to evaluate analgesic effects Bupivacaine, Bupivacaine plus Dexmedetomidine and Bupivacaine plus Fentanyl in relieving pain after knee arthroscopic surgery.

Forty-five patients ASA I - II aged 21-45 years for elective knee arthroscopy were divided into 3 groups: Group B, BD and BF. Group B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline. Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug). Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug). The time of first request of analgesia and analgesic effect by VAS during the first 24 hr. postoperatively are recorded.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Analgesia

Interventions

DexmedetomidineDRUG

Group BD received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml dexmedetomidine (100 ug).

FentanylDRUG

Group BF received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 fentanyl (50 ug)

BupivacainDRUG

Group B received Intra-articular injection of 20 ml bupivacaine 0.25%+ 1 ml saline.

Eligibility

Sex: ALLMin age: 21 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Either sex, * Age 21-45 years, * American Society of Anesthesia (ASA) I - II for elective knee arthroscopy. Exclusion Criteria: * The patients with history of hepatic and renal diseases, psychiatric disorders, * Prolonged intake of (NSAIDS, opioids and tricyclic antidepressant), * Allergy to study drugs and patient who received analgesics up to 24 hr. before surgery were excluded from this study.

Locations (1)

Zagazig university

Zagazig, Egypt

Outcomes

Primary Outcomes

Duration of postoperative analgesia

start from intra-articular injection of the drug to the time of first request of analgesia

Time frame: For 24 hours postoperative

Secondary Outcomes

total dose of rescue analgesia ( pethidine)

total consumption of rescue analgesia (pethidine) postoperative

Time frame: within 24 hours postoperative

The number of participants with bradycardia, itching and hypotension

The number of participants with bradycardia less than 50 beat per minute, itching and hypotension if mean arterial blood pressure less than 20% of basal )

Time frame: Within 24 hours postoperative

patient satisfaction

Patient satisfaction by five point Likert-Like verbal rating scale by asking the patient how they evaluate the experience with the analgesic management after the the surgery? (5-very satisfied, 4-satisfied, 3-neutral, 2-dissatisfied, 1-very dissatisfied)

Time frame: within 24 hours postoperative

pain intensity at rest (static)

measured by VAS on 0-10 cm scale (0- no pain and 10-the worst pain)

Time frame: measured immediately preoperative 0 minute ( admission receiving area)

pain intensity at rest (static)