Cardiovascular diseases (CVDs) continue to be the primary cause of illness and death globally, emphasizing the pressing requirement for efficient prevention methods. Recent studies indicate that the gut microbiome plays a vital role in maintaining cardiovascular health, affecting the pathophysiological mechanisms related to CVDs. The potential therapeutic strategies for primary care practitioners included the modulation of the gut microbiome through dietary changes, prebiotics, and probiotics. The aim of this study was to investage the effect of gut microbiome modulation on clinical outcomes after cardiac surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Enrollment
500
Intestinal Microbiota Transplant (IMT) Capsules were administered 7 days preoperatively and 14 days postoperatively.
Beijing Anzhen Hospital
Beijing, Beijing Municipality, China
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, Guangdong, China
The First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
West China Hospital of Sichuan University
Chengdu, Sichuan, China
Shanghai East Hospital, Tongji University
Shanghai, China
Acute Gastrointestinal Injury
Time frame: 14 days after surgery
ΔSOFA
the difference between the mean total postoperative SOFA score and baseline score within 24 hours of surgery during the index admission
Time frame: 7 days after surgery
30-day mortality rate
defined as mortality within 30 days postoperatively in the hospital or anywhere after discharge;
Time frame: 30 days after surgery
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