Effect of Cocoa Supplementation in Training Athletes Microbiota and Metabolome

Universidad Europea de Madrid40 enrolled

Overview

It has recently been suggested that cocoa may improve exercise performance and recovery. This study aim to evaluate the plasma and fecal metabolome after 10 weeks of cocoa supplementation during the training period in recreational athletes to detect possible metabolites involved in the observed benefits of cocoa in athletes

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

Healthy Athletes

Interventions

cocoaDIETARY_SUPPLEMENT

Sachets of 5 grams of cocoa daily supplementation

PlaceboDIETARY_SUPPLEMENT

Sachets of 5 grams of maltodextrin daily supplementation

Eligibility

Sex: MALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18-45 years of age * high physical condition (VO2 ≥ 55 ml/kg/min) * BMI 18-25 kg/m2 Exclusion Criteria: * antibiotics intake during 3 months prior to the study, * smoking * nutritional complements * ergogenic complements * prebiotics * probiotics * vegetarian or vegan diet * chronic medication * gastrointestinal surgery * Any diagnosed disease

Locations (1)

Universidad Europea de Madrid

Villaviciosa de Odón, Madrid, Spain

Outcomes

Primary Outcomes

Fecal microbiota

Abundance of bacterial taxa determined by 16SRNAr gene sequencing

Time frame: Changes from baseline to 10 weeks of intervention

Fecal metabolome profile

Abundance of fecal metabolites, metabolic networks, and metabolic pathways determined by High Pressure Liquid Chromatography-Mass Spectrometry

Time frame: Changes from baseline to 10 weeks of intervention

Plasma metabolome profile

Abundance of blood metabolites, metabolic networks, and metabolic pathways activity determined by High Pressure Liquid Chromatography-Mass Spectrometry

Time frame: Changes from baseline to 10 weeks of intervention

Data from ClinicalTrials.gov

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