Osteosarcopenia designates the simultaneous presence of sarcopenia and osteopenia; both chronic conditions of advanced age. Dynamic-resistance exercise (DRT) might be the most powerful agent to fight osteosarcopenia. Indeed, in the present FrOST study, we clearly determine the positive effect of slightly adapted 18 month high-intensity (HIT)-DRT on bone mineral density (BMD), sarcopenia and other health related parameters in osteosarcopenic men. However, after a short training break, COVID-19 induced lock down prevented a re-start of the HIT resistance exercise training in the FrOST cohort. The aim of the present observational study is thus to determine the effects of 6 months of deconditioning on health related parameters under special regard of osteosarcopenia in this cohort of older men with osteosarcopenia.
Study Type
OBSERVATIONAL
Enrollment
21
Institute of Medical Physics, Friedrich Alexander University Erlangen-Nürnberg
Erlangen, Bavaria, Germany
SMI
Skeletal muscle mass index (appendicular skeletal muscle mass / body height; kg/m2) as determined by Dual Energy x-Ray Absorptiometry
Time frame: Change from Baseline to 26 weeks
BMD-LS
Bone Mineral Density at the Lumbar Spine as determined by Dual Energy x-Ray Absorptiometry
Time frame: Change from Baseline to 26 weeks
BMD-hip
Bone Mineral Density at the total hip as determined by Dual Energy x-Ray Absorptiometry
Time frame: Change from Baseline to 26 weeks
Sarcopenia-Z-Score
Z-Score of parameters constituting the metabolic syndrome (i.e. SMI, hand-grip strength, gait velocity)
Time frame: Change from Baseline to 26 weeks
Fat infiltration thigh muscles
Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging
Time frame: Change from Baseline to 26 weeks
Fat infiltration para-vertebral muscles
Intramuscular adipose tissue at the mid thigh as determined by Magnetic Resonance Imaging
Time frame: Change from Baseline to 26 weeks
Maximum hip-/leg extensor strength
Maximum hip-/leg extensor strength as determined by an isokinetic leg press
Time frame: Change from Baseline to 26 weeks
Metabolic Syndrome Z-Score
Metabolic Syndrome Z-Score based on the definition of the International Diabetes Federation including waist circumference, resting glucose, HDL-cholesterol, triglyzerides, mean arterial blood pressure)
Time frame: Change from Baseline to 26 weeks
Self rated physical performance
Late-Life Function and Disability Index of McAuley et al.
Time frame: Change from Baseline to 26 weeks
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