Precision Therapy in Complex High-risk Coronary Artery Disease

Inclusion Criteria: * Bifurcation lesions with branch diameter ≥2.5mm; * Chronic complete occlusion (occlusion duration ≥3 months); * Left main disease; * Long lesions (≥38mm); * Multi-vessel percutaneous coronary intervention (simultaneous treatment of ≥2 epicardial vessels during one operation); * Multi-stent implantation (≥3 stents); * In-stent restenosis; * Moderate to severe calcification on radiography; * Intermediate lesion; * Thrombotic lesions; * Creatinine clearance rate \< 60ml/min) or on dialysis ; * Left ventricular ejection fraction \<40% ； * History of cerebral hemorrhage or massive hemorrhage of gastrointestinal tract. Exclusion Criteria: * Informed consent cannot be obtained; * Life expectancy \< 1 year.