A Randomized, Placebo-controlled Clinical Trial of Teneligliptin as Quadruple Oral Combination Therapy for Type 2 DM After Failure of an Oral Triple Anti-diabetic Regimen

Inclusion Criteria: 1. Age over 18 years and less than 81 years 2. Patients with type 2 diabetes prescribed with triple combination of oral antidiabetic drugs more than 12 weeks with sufficient doses (metformin \>= 1000mg/d, Glimepiride \>=4 mg/day, Gliclazide \>= 60 mg/day, SGLT-2 inhibitor with approved dose by Korea FDA) 3. Uncontrolled hyperglycemia with 7.1% ≤ HbA1c ≤ 9% at randomization period 4. Recommended to use insulin by physicians 5. Patients able to understand study protocol and cooperative 6. Voluntary consent to participation of study after understanding study protocol Exclusion Criteria: 1. Type 1 diabetes, gestational diabetes, other than type 2 diabetes 2. Insulin treatment more than 1 week (not necessarily continuous use) prior to screening visit within 1 year 3. Hypersensitivity to TENELIA tablet including main and other component 4. Use of DPP4 inhibitor more than 1 week prior to screening visit within 3 months or discontinuation of DPP4 inhibitor due to severe side effects regardless of treatment period 5. History of acute or chronic metabolic acidosis and ketosis including diabetic ketoacidosis with/without comma prior to screening visit within 12 weeks 6. Genetic trait of galactose intolerance, Lapp lactase deficiency, or glucose-galactose mal-absorption 7. Difficulty in oral ingestion of drug owing to anatomical abnormalities in head and neck area, or owing to abnormalities in central nervous system 8. Steroid use including per oral and non-oral more than 14 consecutive days prior to screening visit within 8 weeks (inhaled steroid use is permitted) 9. Histories of any malignancy prior to screening visit within 5 years 10. History of congestive heart failure (\>= 10) NYHA class III) 11. Uncontrolled arrhythmia, unstable angina, myocardial infarction, stroke, transient ischemic attack, cerebrovascular disease prior to screening visit within 24 weeks 12. Initiation of statin to treat dyslipidemia prior to screening visit within 4 weeks or anticipated increasing dose of statin during study period 13. Renal failure, chronic kidney disease stage \<=3 (estimated glomerular filtration rate \<30 mL/min/1.73 m2, calculated using EKD-EPI) or patients with dialysis 14. Abnormalities in liver function test: AST, ALT, or ALP \>= 2.5 fold of ULN or patients with liver cirrhosis (Child-Pugh class B or C) 15. Infection of HIV, HBV, or HCV and patients subjected to anti-viral therapy within 1 year 16. Pregnant or lactating women; or planning to be pregnant 17. Patients with other severe infection or with severe injuries, or patients expecting any surgery with transient insulin use for peri-operational glucose control 18. Alcohol or any psychotropic substances dependancy , or dependency of any unapproved substances 19. Last visit of other clinical trials for treatment purposes prior to screening visit within 30 days 20. Other inappropriate properties judged by researchers