Venous Disease Thromboembolic and Amyotrophic Lateral Sclerosis

University Hospital, Brest227 enrolled

Overview

Venous thrombo-embolic (VTE) rates could be high in patients with amyotrophic lateral sclerosis (ALS). Indeed, the rate of VTE in this specific population could be 7-fold higher in this population. Predictiv factors of VTE in patients with ALS are mobility reduction and neurological paralysis. However, to our knowledge, medical littérature is poor concerning VTE and ALS association. Our first aim is to define annual rate of VTE in ALS population.Then we aim to identify predictiv factors of VTE in this specific population. The studied population is Brest universitary hospital cohort of ALS patient included between 2000 and 2019.

Study Type

OBSERVATIONAL

Enrollment

227

Conditions

Lateral Amyotrophic Sclerosis Venous Thrombo-embolic Desease

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * patients with amyotrophic lateral sclerosis defined by revised El Escorial score criteria followed in competence centre of Brest Universitary Hospital during 2000 to 2019 Exclusion Criteria: * no consent * other neuro-degenerativ diseases

Locations (1)

CHRU de Brest

Brest, France

Outcomes

Primary Outcomes

Number of venous thrombo-embolic eventsrate per year in amyotrophic lateral sclerosis patients followed between 2000 and 2019 in Brest universitary hospital

pulmonary embolism and deep venous thrombosis

Time frame: 19 years

Secondary Outcomes

Number of predictiv factors of venous thrombo-embolism events in amyotrophic lateral sclerosis population followed in Brest universitary hospital between 2000 and 2019

immobilization, impairment of respiratory function,, mecanical ventilation, denutrition, artificial nutrition

Time frame: 19 years