Evaluation of non-invasive prognostic parameters in patients developing ACLF and renal failure in patients receiving and not receiving transjugular intrahepatic portosystemic shunt (TIPS). Patients are cared according to the local standardized follow up program. Clinical and laboratory data from standard patient care are evaluated for potential prognostic value.
NECTAR consists of patients with ACLF and renal failure with and without receiving transjugular intrahepatic portosystemic shunt (TIPS) at the Department of Internal Medicine I, University of Bonn, Germany and receiving a structured routine evaluation and follow up program. The diagnosis of cirrhosis was based on clinical, hemodynamic and biochemical parameters, and ultrasound and/or biopsy criteria.
Study Type
OBSERVATIONAL
Enrollment
1,000
University Hospital Bonn
Bonn, Germany
RECRUITINGSurvival
death, liver transplantation
Time frame: up to 10 years
Ascites
Evaluation of amount of ascites according to the Child-Score
Time frame: up to 10 years
Hepatic Encephalopathy
Evaluation of the grade according to the West Haven Criteria
Time frame: up to 10 years
Variceal Bleeding
Assessment of presence of variceal bleeding
Time frame: up to 10 years
Liver Failure
defined as Bilirubin level ≥ 12mg/dl
Time frame: up to 10 years
Acute-on-Chronic Liver Failure
Presence of ACLF according to the EASL-Chronic liver Failure Consortium (CLIF)-criteria
Time frame: up to 10 years
Kidney Failure
Assessment of AKI according to KDIGO
Time frame: up to 10 years
Organ Failures
Assessment of Organ failures according to CLIF-Sequential Organ Failure Assessment (SOFA) Score
Time frame: up to 10 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.