Effects of a 12-week Combined Exercise Program on Ghrelins in Obese Adolescent Girls

Pusan National University Yangsan Hospital30 enrolled

Overview

This study aimed to explore the effects of a 12-week combined exercise on ghrelin O acyl transferase, acylated ghrelin and desacylated ghrelin levels in obese girls.

Little is known about on ghrelin O acyl transferase (GOAT), acylated ghrelin (AG) and desacylated ghrelin (DAG) levels during long-term exercise in adolescent population. Our previous study showed that combined exercise program in overweight children increases DAG with unchanged AG. This study aimed to explore the effects of a 12-week combined exercise on GOAT, AG, and DAG in obese girls.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

DOUBLE

Enrollment

Conditions

Ghrelin

Interventions

Combined exercise programOTHER

Combined exercise programme, consisting of warm-up, aerobic exercise, resistance training, and cool-down, 3 days a week after school for 50 minutes from 17;30 under supervision by a trainer plus 300 kcal deficit diet

ControlOTHER

300 kcal deficit diet only

Eligibility

Sex: FEMALEMin age: 16 YearsMax age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * girls between 16 and 18 years * being classified as being overweight or obese defined with the 85th percentile of body mass index or above based on the 2007 growth chart for Korean children aged 2-18 years. * After consultation with a physician, they were required to be considered physically healthy enough to engage in regular exercise after school. Exclusion Criteria: * participation in any weight-management programme in the past 6 months * engagement in other exercise programs except for regular physical education at school * smoking * amenorrhea for consecutive 2 months or more * being treated for hereditary diseases, mental disorder, hypertension, diabetes mellitus, or musculoskeletal impairments * taking any medication or supplements for weight control

Locations (1)

Pusan National University Yangsan Hospital

Yangsan, Gyeungsangnam-do, South Korea

Outcomes

Primary Outcomes

body fat percent

Changes in body fat percent during 12 weeks

Time frame: Change from baseline body fat percent at 12 weeks

acylated ghrelin

Changes in concentrations of acylated ghrelin during 12 weeks

Time frame: Change from concentrations of baseline acylated ghrelin at 12 weeks

desacylated ghrelin

Changes in concentrations of desacylated ghrelin during 12 weeks

Time frame: Change from concentrations of baseline desacylated ghrelin at 12 weeks

Secondary Outcomes

ghrelin O acyl transferase

Changes in concentrations of ghrelin O acyl transferase during 12 weeks

Time frame: Change from baseline concentrations of ghrelin O acyl transferase at 12 weeks

Data from ClinicalTrials.gov

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