Clinical Trial of SL1904B CAR-T Cells for Relapsed or Refractory Non-Hodgkin Lymphoma

Inclusion Criteria: 1. Sign the informed consent form and be willing and able to comply with the visit, treatment regimen, laboratory examination and other requirements of the study as stipulated in the trial flow chart; 2. The diagnosis of patients with relapsed or refractory non-hodgkin lymphoma; 3. There should be at least one measurable tumor focus according to the RECIST version 1.1; 4. ECOG Scores: 0\~2; 5. The expression of CD19 on the tumor cells was reported as positive by either immunohistochemistry or flow cytometry; 6. Estimated survival time was longer than 3 months; 7. main organ functions shall meet the following requirements including: serum creatinine ≤1.5 times the upper limit of normal value (ULN); ALT ULN 2.5 or less; AST ULN 2.5 or less; Total bilirubin ≤ 1.5ULN; Left ventricular ejection fraction (LVEF) ≥45%; Hemoglobin ≥90g/L; Platelet count ≥50×109/L; absolute Neutrophil count (ANC) ≥1.0×109/L; Blood oxygen saturation \>92%； 8. Peripheral blood mononuclear immune cells must be collected at least 2 weeks after the last radiotherapy or systemic treatment. Exclusion Criteria: 1. Serious cardiac insufficiency； 2. Has a history of severe pulmonary function damaging; 3. With other tumors which is/are in advanced malignant and has/have systemic metastasis; 4. Merging the metabolic diseases (except diabetes); 5. Merging severe autoimmune diseases or immunodeficiency disease; 6. Patients with active hepatitis B or hepatitis C virus infection; 7. Patients with HIV infection or syphilis infection; 8. Has a history of serious allergies on Biological products (including antibiotics); 9. Participated in any other clinical drug trial for the last six months; 10. Being pregnant and lactating or having pregnancy within 12 months; 11. With other uncontrolled diseases and considered not suitable to participate by the researchers; 12. Any situations that the researchers believe will increase the risks for the subject or affect the results of the study.