Polycystic Ovary Syndrome and BETATROPHIN

Hatice Akkaya73 enrolled

Overview

This is an original study giving an information about the association body mass index, polycystic ovary syndrome and betatrophin.

Introduction: Betatrophin is a protein hormone which has a significant role in glucose homeostasis and lipid metabolism. The aim of this study is to compare the levels of serum betatrophin in overweight and normal weight women with PCOS. Material and Method: Thirty-five patients normal weight women with PCOS (BMI\<25) and 38 obese women with PCOS (BMI≥25) were included in this prospective, cross-sectional study. Patients were selected according to Rotterdam criteria. Serum betatrophin levels were studied by ELISA method and then compared between these two groups besides the following additional parameters as waist circumference/hip circumference ratio, fasting blood glucose, 75 g OGTT (oral glucose tolerance test) results and HOMA-IR levels.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Polycystic Ovary Obesity

Interventions

serum marker levelsDIAGNOSTIC_TEST

two groups comparisons

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: -Polycystic ovary syndrome according to 2003 Rotterdam PCOS Consensus diagnostic criteria Exclusion criteria * pregnancy, * an additional systemic disease (i.e.,hyperprolactinemia, thyroid dysfunction, liver or kidney diseases, cardiovascular disease, hyperlipidemia, type 1 or type 2 diabetes, chronic or acute infection within the previous 30 days), * morbid obesity, * smoking, * the use of medications for contraception, androgen excess, hypertension, hyperglycemia or dyslipidemia at least 3 months before the study.

Locations (1)

Kayseri Doğumevi

Kocasinan, Kayseri, Turkey (Türkiye)

Outcomes

Primary Outcomes

serum Betatrophin levels

ng/L

Time frame: 30 min

Secondary Outcomes

Waist/hip ratio

centimeter

Time frame: 5 min

75 gr OGTT(oral glucose tolerance test)

(mg/dl)

Time frame: 2 hours

BMI (body mass index)

kg/m2

Time frame: 5 minute

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.