Characterization of Reverse Triggering and Other Asynchronies in COVID-19 Patients Under Invasive Mechanical Ventilation

Corporacion Parc Tauli32 enrolled

Overview

Prospective observational trial in patients admitted to ICU diagnosed with COVID-19 requiring invasive mechanical ventilation. Characterization of Reverse Triggering asynchrony during the first 5 days of invasive mechanical ventilation and other asynchronies, and its correlation with different outcomes.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Mechanical Ventilation Complication

Interventions

Asynchronies detectionDIAGNOSTIC_TEST

Asycnhronies detection

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients under invasive mechanical ventilation more than 24 hours and with a minimum of 48 hours of respiratory signals registered from the ventilator * Diagnosis of COVID-19 Exclusion Criteria: * less than 48 hours of data, * age \< 18 years * admitted from other centers under invasive mechanical ventilation.

Locations (1)

Candelaria de Haro

Sabadell, Barcelona, Spain

Outcomes

Primary Outcomes

Incidence and pattern of presentation of Reverse triggering in COVID-19 patients under invasive mechanical ventilation

To analyze the incidence of Reverse Triggering in the initial phases of invasive mechanical ventilation in COVID-19 patients

Time frame: during the 5 first days of invasive mechanical ventilation

Secondary Outcomes

Incidence of Reverse Triggering related to the level of sedation in COVID-19 patients under invasive mechanical ventilation

To correlate the presence of Reverse Triggering with the level of sedation and use of neuromuscular blockers

Time frame: From the day of mechanical ventilation initation up to 5 days or the last day of mechanical ventilation

Reverse triggering and secondary asynchronies in COVID-19 patients under invasive mechanical ventilation

To analyze the incidence of breath stacking and ineffective efforts secondary to RT.

Time frame: From the day of mechanical ventilation initiation up to 5 days

Incidence and pattern of presentation of asynchronies in COVID-19 patients under invasive mechanical ventilation

To analyze the incidence of RT, ineffective efforts and double triggering throughout the period of invasive mechanical ventilation

Time frame: Each day from the day of mechanical ventilation initiation until the day of mechanical ventilation withdrawal or up to 28 days

Influence of asynchronies in different outcomes in in COVID-19 patients under invasive mechanical ventilation

To correlate the presence of asycnhronies and its type with duration of invasive mechanical ventilation, ICU length of stay and survival

Time frame: Each day from the day of mechanical ventilation initiation until the end of invasive mechanical ventilation, ICU discharge and hospital discharge or up to 28 days

Data from ClinicalTrials.gov

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