This project aims to systematically and deeply study the central mechanism of tinnitus using electroencephalogram, and further study the treatment mechanism of tinnitus in combination with sound treatment strategies, so as to provide a research basis for clinical treatment of tinnitus.
Tinnitus is one of the most common auditory disturbances in human. The treatment of tinnitus is always not effective, and the standardized treatment of tinnitus has been lacking. With the development of neuroimaging, neuroelectrophysiology and animal models of tinnitus, the central mechanism of tinnitus has been gradually revealed. The possible mechanisms of tinnitus are the increase of spontaneous discharge rate and synchronization of auditory central neurons caused by hearing deprivation, the change of brain topological structure, the reorganization of auditory cortex, and the disorder of limbic system and auditory central regulation of tinnitus patients. EEG, as an important means to study the cerebral cortex, has become an important technical support for the research on the central mechanism of tinnitus. Changes in activity in auditory brain areas associated with tinnitus have been observed using EEG/ERPs, and non-auditory brain areas such as the limbic system and frontal cortices have also been associated with tinnitus mechanisms. This project aims to systematically and deeply study the central mechanism of tinnitus using electroencephalogram, and further study the treatment mechanism of tinnitus in combination with sound treatment strategies, so as to provide a research basis for clinical treatment of tinnitus.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
100
music therapy: therapeutic sound according to the frequency and loudness of each patient's tinnitus sound, so as to reduce the tinnitus sound.
electroencephalogram evaluation
latency
Time frame: From date of randomization, assessed every 3 month, up to 24 month
electroencephalogram evaluation
peak
Time frame: From date of randomization, assessed every 3 month, up to 24 month
electroencephalogram evaluation
amplitude
Time frame: From date of randomization, assessed every 3 month, up to 24 month
the loudness of tinnitus
estimated by auditory facility, recorded by unit of dB
Time frame: From date of randomization, assessed every 3 month, up to 24 month
the frequency of tinnitus
estimated by auditory facility, recorded by unit of Hz
Time frame: From date of randomization, assessed every 3 month, up to 24 month
minimum masking level
the minimum volume to masking tinnitus, recorded by unit of dB
Time frame: From date of randomization, assessed every 3 month, up to 24 month
Tinnitus Handicapped Inventory
Tinnitus disability is divided into four levels, the first level: 0-16 points, no disability; Level 2:18-36, slightly disabled; Level 3:38-56, moderate disability; Level 4:58-100, severe disability.
Time frame: From date of randomization, assessed every 3 month, up to 24 month
Hospital Anxiety and Distress Scale
0-7 are asymptomatic; 8 -10 respectively belong to suspicious existence; 11 -21 must exist.
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Time frame: From date of randomization, assessed every 3 month, up to 24 month