Immunoadsorption Versus High-dose Intravenous Corticosteroids in Relapsing Multiple Sclerosis

Inclusion Criteria: * Signed informed consent form * Diagnosis of relapsing-remitting multiple sclerosis according to 2017 revised McDonald-criteria * Incomplete remission of relapse symptoms following initiation treatment with 1000mg/d intravenous methyl prednisolone * Absence of fever or clinically apparent signs of infection Exclusion Criteria: * Baseline EDSS score \>6.5 points * Previous administration of less than 3x1000mg or more than 5x1000mg IVMPS for initiation treatment * Known pregnancy or rejection to perform a pregnancy test (female patients only) * Immunosuppressive treatment for conditions other than multiple sclerosis * Ongoing neoplastic disorder or past neoplastic disorder within previous five years * Known or newly diagnosed HIV-, HBV- or HCV-infection * Regular intake of ACE inhibitor drugs * Known bleeding disorders (including laboratory abnormalities such as: (I) platelet count\<50.000/µL; (II) international normalized ratio\>1.5, (III) activated prothrombin time\>50s) or intake of oral anticoagulant drugs