Histamine H1/H2 Receptors and Training Adaptations

University Ghent19 enrolled

Overview

Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

QUADRUPLE

Enrollment

Conditions

Exercise Training Physical Activity

Interventions

LactoseOTHER

Placebo: Lactose capsules

Fexofenadine HydrochlorideDRUG

H1 receptor antagonist: 540 mg Fexofenadine Hydrochloride

FamotidineDRUG

H2 receptor antagonist: 40 mg Famotidine

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Sedentary or low levels of physical activity * Caucasian Exclusion Criteria: * Chronic diseases * Medication use * Smoking * Excessive alcohol consumption * Seasonal allergies

Locations (1)

Department of Movement and Sports Sciences, Ghent University

Ghent, Oost-Vlaanderen, Belgium

Outcomes

Primary Outcomes

Change in cardiorespiratory fitness

Change in maximal oxygen uptake during incremental cycling test on cycle ergometer during the 6 week training period

Time frame: Before, after 3 weeks and after 6 weeks of exercise training

Change in peak aerobic power output

Change in peak power output during incremental cycling test on cycle ergometer during the 6 week training period

Time frame: Before, after 3 weeks and after 6 weeks of exercise training

Change in whole-body insulin sensitivity

Change from baseline in Matsuda index for whole-body insulin sensitivity derived from Oral Glucose Tolerance Test after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in microvascular function

Change from baseline in microvascular function (Single Passive Leg Movement technique) after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Secondary Outcomes

Change in skeletal muscle capillarization

Change from baseline in skeletal muscle capillarization (immunohistochemistry) after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in skeletal muscle enzyme activity

Change from baseline in enzyme activity assessment of markers of relevance for skeletal muscle function after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in skeletal muscle protein content

Data from ClinicalTrials.gov

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Change from baseline in Western Blot assessment of markers of relevance for skeletal muscle function after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in power output at Gas Exchange Threshold (GET)

Change from baseline in GET during incremental cycling test after the 6 week training period

Time frame: Before, after 3 weeks and after 6 weeks of exercise training

Change in power output at Respiratory Compensation Point (RCP)

Change from baseline in RCP during incremental cycling test after the 6 week training period

Time frame: Before, after 3 weeks and after 6 weeks of exercise training

Change in time to exhaustion performance test

Change in time to exhaustion test (performed after incremental cycling test) during the 6 week training period

Time frame: Before, after 3 weeks and after 6 weeks of exercise training

Change in heart rate during submaximal cycling

Change from baseline in heart rate during submaximal cycling after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in substrate oxidation during submaximal cycling

Change from baseline in substrate oxidation during submaximal cycling test (estimated via gas exchange data) after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in blood lactate accumulation during submaximal cycling

Change from baseline in capillary lactate concentration at end of submaximal cycling test after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in cycling efficiency during submaximal cycling

Change from baseline in cycling efficiency (estimated via gas exchange data) after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in fasted serum insulin concentrations

Change from baseline in fasted blood concentrations of insulin after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in fasted serum glucose concentrations

Change from baseline in fasted blood concentrations of glucose after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in fasted serum cholesterol concentrations

Change from baseline in fasted blood concentrations of cholesterol after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in fasted serum triglyceride concentrations

Change from baseline in fasted blood concentrations of triglyceride after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in resting blood pressure

Change from baseline in resting mean arterial blood pressure after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in resting heart rate

Change from baseline in resting heart rate after the 6 week training period

Time frame: Before and after 6 weeks of exercise training

Change in body weight

Change from baseline in total body weight after the 6 week training period

Time frame: Before and after 6 weeks of exercise training