A Study of LY3209590 in Participants With Type 1 Diabetes

Change From Baseline in Fasting Serum Glucose

LS mean change from baseline was analysed by mixed model repeated measures (MMRM) model with treatment, country, HbA1c stratum, visit, and treatment by visit interaction as fixed effects and the baseline fasting serum glucose as a covariate.

Time frame: Baseline, Week 26

Change From Baseline in Bolus Insulin Dose

Bolus insulin dose was the sum of doses for morning, midday, evening meals, snack and correction. LS mean change from baseline was analysed by MMRM model with treatment, country, HbA1c stratum, visit, and treatment by visit interaction as fixed effects and the baseline bolus insulin dose as a covariate.

Time frame: Baseline, Week 26

Rate of Documented Hypoglycemia

Documented hypoglycemia is defined as any time a participant reports a self-monitoring blood glucose \<54 mg/dL (3.0 millimole per liter (mmol/L)). Negative binomial model using baseline hypoglycaemia incidence, baseline HbA1c and treatment as independent variables was performed to estimate the event rate. Data presented is group mean. Group Mean is estimated by first taking the inverse link function on individual participant covariates, then averaging over all participants.

Time frame: Baseline through Week 26

Pharmacokinetics (PK): Area Under the Concentration Time Curve (AUC) of LY3209590