The purpose of this research is to assess the analgesic and subjective effects of terpenes administered alone and in combination of THC.
The overall aim of this placebo-controlled study is to examine dose-dependent analgesia, intoxication, abuse liability, and pharmacokinetics of ecologically relevant doses of vaporized myrcene and beta-caryophyllene administered alone or with vaporized THC.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
45
Vaporized THC (5 mg)
Vaporized THC (15 mg)
Vaporized Myrcene (0.5 mg)
University of California, Los Angeles
Los Angeles, California, United States
Analgesia as measured using the Cold Pressor Test
Pain threshold and pain tolerance assessed using the Cold Pressor Test
Time frame: 7 hours
Subject-rated drug effects of abuse liability
Subject ratings of "Good Drug Effect" as measured using a visual analog scale (1-100 mm)
Time frame: 7 hours
Subject-rated drug effects of intoxication
Subject ratings of "High" as measured using a visual analog scale (1-100 mm)
Time frame: 7 hours
Subjective ratings of pain
Subject ratings of Painfulness and Bothersomeness of the Cold Pressor Test
Time frame: 7 hours
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Vaporized Myrcene (12.0 mg)
Vaporized Beta-Caryophyllene (0.5 mg)
Vaporized Beta-Caryophyllene (7.5 mg)
Vaporized Placebo