Predictive Factor Study of the Occurrence of Endometrial Cancer in Patients With Lynch Syndrome

University Hospital, Lille150 enrolled

Overview

Lynch Syndrome increases Endometrial Cancer Occurrence in women due to failure in MisMatch Repair System. Lifetime Cumulative risk of developing endometrial Cancer is approximatively 40% in women with Lynch Syndrome. Endometrial cancer is the third women cancer in France. Many risk factors are known in general population. Lots of factors are related to over exposure to estrogen. Data about influence of general risk factors in Women with Lynch Syndrome are poor. Recently, a cohort study appears to have shown a significant decrease in the risk of endometrial cancer with multiparity, the use of hormonal contraception and late menopause in Lynch women. The impact of weight and certain metabolic parameters on the occurrence of endometrial cancers remains poorly known to this day.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Lynch Syndrome

Interventions

questionnaire assesmentOTHER

Each patient will to answer questions about their medical history.

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * Lynch Syndrome Diagnosis at University Hospital * Alive at study time * Age over 30 at endometrial cancer or Lynch Syndrome Diagnosis Case group : \- No cancer before endometrial cancer diagnosis Control group : * No endometrial cancer developped * Free cancer women at Lynch Syndrome diagnosis Exclusion Criteria: * Refusing to participate * Poor understanding of the French language * Other cancer diagnosed before endometrial cancer * Hysterectomy before lynch diagnosis for free cancer women

Outcomes

Primary Outcomes

Correlation between endometrial cancer and predictif factors

Endometrial cancer (yes/no) and explicative variable: Diabetes before endometrial cancer or Lynch syndrome diagnosis; Smoking ; Maximal Weight ; Age at menarche; Parity ; Age at first birth ; Contraceptive use.

Time frame: Baseline

Secondary Outcomes

Correlation between endometrial cancer and predictif factors in post menopausal woman

Endometrial cancer (yes/no) and explicative variable: Menopause age; Hormonal menopause treatment