Hepatitis C Virus (HVC) Positive Heart Grafts in HCV Negative Recipients

Inclusion Criteria: * Male or female * Age 18 and older * Active on the transplant list * Donor organ with Antibody and NAT (nucleic acid test) positive for HCV * HCV negative recipient; this includes patients who never had HCV and those with HCV previously eradicated with antiviral therapy. The latter is defined as those with undetectable HCV viral load at least 3 months since stopping therapy. * Willing and able to provide written informed consent or for those subjects where hepatic encephalopathy affects their ability to provide initial or ongoing consent, has an appropriate and legally-authorized representative willing and able to provide consent on behalf of the subject * Patients listed for multiple organ transplant (heart and kidney or heart and liver) can be included based on agreement of non-cardiac organ transplant team Exclusion Criteria: * Participants co-infected with HIV * Donor previously treated with an NS5a containing regimen (if treatment history of donor known) * Known allergies or hypersensitivity to DAA or ribavarin * Pregnancy and/or actively breastfeeding