Hormonal and Metabolic Aspects of Endoscopic Sleeve Gastroplasty

Hvidovre University Hospital

Overview

The investigators of the study want to investigate the complex interactions between glucose metabolism, food intake/weight loss, and different appetite regulating hormones after ESG in comparison with conventional laparoscopic sleeve gastrectomy (LSG).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Conditions

Endoscopic Sleeve Gastroplasty Laparoscopic Sleeve Gastrectomy Gut Hormones Glucose Metabolism Disorders

Interventions

Endoscopic sleeve gastroplastyPROCEDURE

Four-hour solid mixed meal test

Laparoscopic sleeve gastrectomyPROCEDURE

Four-hour solid mixed meal test

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years * Scheduled for endoscopic or laparoscopic sleeve at Hvidovre Hospital * HbA1c \< 48 mmol/mol before surgery, and no history of diabetes * HbA1c \< 48 mmol/mol and fasting plasma glucose \< 6.1 mmol/l at inclusion * BMI\<45 Exclusion Criteria: * Hemoglobin \< 6.5 mmol/l at inclusion * Pregnancy or breast feeding * Medication affecting the planned examinations

Locations (1)

Department of Endocrinology, Hvidovre University Hospital

Copenhagen, Hvidovre, Denmark

Outcomes

Primary Outcomes

Changes in ghrelin (pg/ml)

Changes in ghrelin after a solid meal test compared before and after surgery

Time frame: 240 minutes

Secondary Outcomes

Changes in gut hormone response before and after sugery (pmol/L)

Time frame: 240 minutes

Data from ClinicalTrials.gov

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