Evaluation of Endoplasmic Reticulum Stress in Patients With Recurrent Pregnancy Loss

Kanuni Sultan Suleyman Training and Research Hospital90 enrolled

Overview

To evaluate endoplasmic reticulum stress in women with recurrent pregnancy loss and those who had healthy births in the same age group. The level of the unfolded protein X box binding protein 1 (XBP-1) is measured. It is aimed to show the effect of endoplasmic reticulum stress on recurrent pregnancy loss.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Recurrent Pregnancy Loss Endoplasmic Reticulum Stress

Interventions

x box binding proteinOTHER

Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * with three or more miscarriages before 20 th week of gestation * had no chronic or acute inflammatory disease * used no steroids, anti-inflammatory, or antioxidant medications Exclusion Criteria: * had inflammatory diseases * had systemic disease * Anatomical abnormalities, infectious, endocrine, or genetic etiologies

Locations (1)

Pinar Yalcin Bahat

Istanbul, İ̇stanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

Show the effect of endoplasmic reticulum stress on recurrent pregnancy loss

Serum value (pg / mL) of x box binding protein (XBP-1), which is one of the unfolded proteins indicating endoplasmic reticulum stress, is measured.

Time frame: 3 months

Data from ClinicalTrials.gov

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