Testing the Noradrenergic Hypothesis of Transcutaneous Vagus Nerve Stimulation

N/AActive Not RecruitingNCT04455295

Arkansas Tech University55 enrolled

Overview

This study investigates the capacity of non-invasive vagus nerve stimulation, applied at the ear, to alter to measures of locus coeruleus output pupil diameter and EEG alpha power. Non-invasive alteration in locus coeruleus output is of interest in regard to basic science and has potential clinical implications in a number of conditions.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Enrollment

Conditions

no Condition Electroencephalography Pupil Diameter

Interventions

Transdermal Vagus Nerve Stimulation (tVNS)DEVICE

Mild non-invasive transdermal electrical stimulation at the ear (0.0-1.0 mA, 0.0-30.0 Hz). Used in previous studies with no unexpected adverse events. Stimulator not considered a FDA regulated device in previous studies.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy, 18 years of age or older. Exclusion Criteria: * self-report of mood disorders, prescription and non-prescription drug use which includes stimulants including caffeine and nicotine

Locations (1)

Arkansas Tech University

Russellville, Arkansas, United States

Outcomes

Primary Outcomes

Pupil Diameter

Pupil diameter is measured via camera.

Time frame: Within single one hour session

EEG Alpha power.

Alpha power will be determined from EEG.

Time frame: Within single one hour session

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.