Approximately 15% of patients with SARS-CoV-2 infection / COVID-19 develop a severe clinical course. This leads to hospitalization and potentially life threatening complications such as pneumonia and respiratory failure. Predictors for early detection and risk stratification are urgently needed. Moreover, only scarce information is available for long-term follow-up and late complications associated with infection. We therefore aimed to find predictors for severe courses of the novel disease as well as to establish strategies for therapeutic monitoring and follow-up.
Study Type
OBSERVATIONAL
Enrollment
100
Thoraxklinik at Heidelberg University
Heidelberg, Germany
TLCO
Transfer factor for carbon monoxide
Time frame: 3-5 days intervals (inpatients)
TLCO
Transfer factor for carbon monoxide
Time frame: 1-6 months (outpatients, follow up)
D5-20
frequency dependence of resistance as measured by oscillometry
Time frame: 3-5 days intervals (inpatients
D5-20
frequency dependence of resistance as measured by oscillometry
Time frame: 1-6 months (outpatients, follow up)
FEV1/FVC
forced expiratory volume in 1 s / forced vital capacity (as measured by spirometry)
Time frame: 3-5 days intervals (inpatients)
FEV1/FVC
forced expiratory volume in 1 s / forced vital capacity (as measured by spirometry)
Time frame: 1-6 months (outpatients, follow up)
comorbidities
structured questionnaire
Time frame: at hospital admission and each follow (every 1-6 months)
clinical symptoms
structured qualitative questionnaire
Time frame: 3-5 days intervals (inpatients), 1-6 months (outpatients, follow up)
St. George's Respiratory Questionnaire total score
validated questionnaire (scores range from 0 to 100, with higher scores indicating more limitations)
Time frame: 3-5 days intervals (inpatients), 1-6 months (outpatients, follow up)
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