The objective of this study is to evaluate the efficacy and safety of a fractional 1,064 nm picosecond laser for the treatment of striae alba.
Striae distensae are atrophic dermal scars that can cause psychosocial distress on affected patients. Despite numerous available therapeutic modalities, no gold standard therapy has been established. Picosecond lasers are a newer advancement in lasers that have primarily used in the treatment of tattoos. A fractional 1064-nm picosecond laser has recently become available for the treatment of pigmentation and skin rejuvenation. The main mechanism of action is tissue ablation via laser induced optical breakdown (LIOB) which occur when pulse intensity is high enough to strip electrons and generating plasma, the plasma absorbs the remaining laser energy forming a cavitation bubble within the dermis which has been demonstrated to improve fine wrinkles and acne scar through the stimulation of collagen formation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
12
The parameter of laser was 8-mm spot size, 0.6 mJ/cm2, 750 ps, 10 Hz, 2 passes. The treatment was done in every 4 weeks for 4 sessions.
Faculty of Medicine, Siriraj hospital, Mahidol University
Bangkok Noi, Bangkok, Thailand
RECRUITINGChange in striae roughness by Antera 3D image
Time frame: change from baseline in striae roughness score at 6 months
Change in average Melanin index by Antera 3D image
Time frame: change from baseline in average melanin index at 6 months
Change in melanin variation index by Antera 3D image
Time frame: change from baseline in melanin variation index at 6 months
Investigator assessment scores
Clinical improvement was evaluated by comparing pre and post photographs by 2 independent investigators.
Time frame: Baseline, 1, 3 and 6 months after final treatment
Patient satisfaction scores
patient satisfaction questionnaire was done by grading on a scale of 0 to 4; 0: no improvement, 1: \<25% improvement, 2: 25-50% improvement, 3: 51-75% improvement, 4: \> 75% improvement
Time frame: Baseline, 1, 3, and 6 months after final treatment
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