Investigation of the Efficacies of a Resveratrol Formula on Improvement of Skin Conditions and Inflammatory Related Factors

N/ACompletedNCT04456829

TCI Co., Ltd.60 enrolled

Overview

To assess a resveratrol formula on improvement of skin conditions and inflammatory cytokines in blood

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Skin Conditions Proinflammatory Cytokines

Interventions

Resveratrol drinkDIETARY_SUPPLEMENT

Subjects will consume a bottle of resveratrol drink for two months.

Placebo drinkDIETARY_SUPPLEMENT

Subjects will consume a bottle of placebo drink for two months.

Eligibility

Sex: ALLMin age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy volunteers aged above 20 years old Exclusion Criteria: * Subject who is not willing to participate in this study. * Patients with diseases of the skin, heart, liver, kidney, endocrine and other organs and patients with mental illness (according to medical history). * Subjects who have known cosmetic, drug or food allergies, difficulty in digestive tract absorption or disorder. * Female who is pregnant or nursing or planning to become pregnant during the course of the study. * Received facial laser therapy, chemical peeling or UV overexposure in the past 4 weeks. * Subjects who have large spots (area \>3 square centimeter) or abnormal acne.

Locations (1)

Chia Nan University of Pharmacy & Science

Tainan, Taiwan

Outcomes

Primary Outcomes

The change of skin moisture

Corneometer® CM825 was utilized to measure skin moisture. Units: arbitrary Corneometer® units 0-120

Time frame: 0, 4, and 8 weeks

The change of skin elasticity

Cutometer® dual MPA 580 was utilized to measure skin elasticity (parameter R2). Units: μm penetration depth into the probe opening, expressed as curves

Time frame: 0, 4, and 8 weeks

The change of skin wrinkles

VISIA Complexion Analysis System was utilized to measure wrinkles. Units: arbitrary units

Time frame: 0, 4, and 8 weeks

The change of skin collagen density

DermaLab® USB - 20 MHz High Freq. Ultrasound probe was utilized to scan and analyze skin collagen density. Units: Intensity score

Time frame: 0, 4, and 8 weeks

The change of skin texture

VISIA Complexion Analysis System was utilized to measure skin texture. Units: arbitrary units

Time frame: 0, 4, and 8 weeks

The change of skin pores

VISIA Complexion Analysis System was utilized to measure skin pores. Units: arbitrary units

Time frame: 0, 4, and 8 weeks

The change of total antioxidant capacity of blood

Total Antioxidant Capacity Assay Kit

Time frame: 0 and 8 weeks

The change of TNF-alpha of blood

ELISA Kit

Time frame: 0 and 8 weeks

Data from ClinicalTrials.gov

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