This is a prospective, single-center, non-randomized, non-controlled observational study.
Almost 55-62% of patients with triple-negative or human epidermal growth factor receptor 2 (HER2) positive, node-positive breast cancer achieve an axillary pathologic complete remission (pCR) after neoadjuvant chemotherapy (NAC). To avoid surgery post-NAC, it is paramount to accurately identify patients who achieve pCR in axillary lymph node (ALN). We found that patients with normal-appearing lymph nodes on computed tomography (CT) based radiomics of the axilla after chemotherapy had a lower risk of developing residual nodal disease. However, the features of CT-based radiomics for pCR ALN following NAC has not been established yet. This study aimed to assess the performance of CT-based radiomics in evaluating the response and predicting pCR of metastatic lymph nodes after NAC in breast cancer patients.
Study Type
OBSERVATIONAL
Enrollment
218
Peking University Cancer Hospital
Beijing, Beijing Municipality, China
RECRUITINGThe features of CT-based radiomics for axillary lymph node achieved pCR after neoadjuvant chemotherapy
Sensitivity, specificity, positive-predictive value (PPV) and negative-predictive value (NPV) of CT-based radiomics for axillary lymph node status after neoadjuvant chemotherapy will be assessed.
Time frame: within 8 weeks after obtaining the post-surgery pathological results
Receiver operating characteristic (ROC) curve analysis
The diagnostic performance of CT-based radiomics for the evaluation of ALN after NAC was evaluated with receiver operating characteristic (ROC) curve analysis. The diagnostic accuracy was estimated by calculating the area under the ROC curve
Time frame: within 8 weeks after obtaining the post-surgery pathological results
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.