Cardiac amyloidosis is an increasingly contributor of degenerative cardiac diseases. However, its frequency remains underestimated, and diagnosis is often realized at late stages of the disease. A larger use of clinical and echographic Red Flag signals during routine echocardiographic examination may enhance the identification of early stage of the disease.
The objective is to evaluate the clinical and epidemiological aspects of cardiac amyloidosis using a systematic screening of even moderate left ventricular hypertrophy, taking into account the presence of Red Flag signals. Red Flag Signals will include history or symptoms of carpal tunnel syndrome, hearing loss, chronic gastrointestinal disorders, heart failure, cervical or lumbar stenosis, or echographic abnormalities such as apical sparring, increased left ventricular filling pressure, atrio-ventricular block.
Study Type
OBSERVATIONAL
Enrollment
424
Cardiac amyloidosis diagnosed according to Gillmore's algorithm
Centre Hospitalier de Basse-Terre
Basse-Terre, Guadeloupe
NOT_YET_RECRUITINGCHU de Martinique
Fort-de-France, Martinique
RECRUITINGCHU de Martinique
La Trinité, Martinique
NOT_YET_RECRUITINGFrequency of cardiac amyloidosis diagnosed according to Gillmore's algorithm
frequency of cardiac amyloidosis diagnosed according to Gillmore's algorithm at the end of the diagnosis procedures, using biological (presence of cell dyscrasia), imaging (myocardial staining of bone tracers), and tissue examination (Congo Red staining) variables
Time frame: 3 months
Frequency genotype of Transthyretin cardiac amyloidosis according to Gillmore's algorithm
Evaluate the frequency of Transthyretin cardiac amyloidosis among subjects with even moderate left ventricular enlargement (wall thickness ≥ 12 mm), taking into account the presence or not of Red Flag signals
Time frame: 5 months
Distribution of Red Flag signals according to Transthyretin genotype
To Compare the distribution of Red Flag signals between wild type TTR cardiac amyloidosis and hereditary TTR cardiac amyloidosis
Time frame: 5 months
Diagnosis value of any Red Flag signal.
To evaluate the diagnostic performance of each of the Red Flag signals for the diagnosis of TTR cardiac amyloidosis
Time frame: 5 months
Elaboration of a pre-test probability score
To elaborate a pre-test probability score including the Red Flag signals, adapted to the Echo Lab settings.
Time frame: 5 months
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