Circulating Exosomes and Endothelial Dysfunction in Patients With Obstructive Sleep Apneas Hypopneas Syndrome

University Hospital, Angers99 enrolled

Overview

Evaluation of miRNA contained in exosomes in obese and OSA patients with endothelial dysfunction evaluated by digital plethysmography (ENDOPAT) compared to obese and OSA patients without endothelial dysfunction.

The aim of the study is to compare the content of exosomes between two goups of 20 patients, with and without endothelial dysfucntion. the endothelial function will be evaluated after polysomnography, on obese patients with OSA (AHI \>15).

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Endothelial Dysfunction

Interventions

ENDOPATDIAGNOSTIC_TEST

digital plethysmography

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult subject * Subject understands the study protocol and is willing and able to comply with study requirements and sign informed consent * Subject with OSA (defined by AHI \>15/h) Exclusion Criteria: * cardiac or vascular desease

Locations (1)

Frédéric GAGNADOUX

Angers, France

Outcomes

Primary Outcomes

miRNA cointained in exosomes

compare exosome content between obese-OSA patients with endothelial dysfunction and without

Time frame: immediately after the consultation

Data from ClinicalTrials.gov

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