Tigerase® Efficacy and Safety as Part of Complex Therapy in Patients With COVID-19

Inclusion Criteria: 1. Written informed consent for participation in the study 2. Men and women aged ≥18 years 3. Laboratory-confirmed diagnosis of coronavirus infection caused by COVID19, moderate severity \* \*Criteria for moderate flow (just one point) Mandatory Criterion * Pneumonia Additional criteria (used to characterize the disease and are not required to determine the severity) * Fever above 38 ° C * respiratory rate more than 22 / min * Shortness of breath during physical exertion * SpO2 \<95% * С-reactive protein (CRP) of serum more than 10 mg / l 4. Patients with pneumonia with a stable level of hemoglobin saturation by oxygen (\> 93%) on oxygen support and / or receiving respiratory support of non-invasive mechanical ventilation Exclusion Criteria: 1. Individual intolerance or hypersensitivity to the active or any of the excipients of the drug Tigerase® 2. The need for invasive mechanical ventilation at the time of inclusion of the patient 3. Patients severe condition (one of the following characteristics): * Respiratory distress syndrome with respiratory rate ≥30 per minute * Saturation of hemoglobin with oxygen ≤93% with oxygen support 4. Patient participate in any clinical trials and / or taking the experimental drug within 30 days before inclusion this trial 5. Severe competitive respiratory system diseases (bronchial asthma, chronic obstructive pulmonary disease - COPD, cystic fibrosis, interstitial lung disease) 6. Positive results of laboratory testing for HIV and hepatitis B and C 7. Life expectancy less than 12 months without COVID-19 8. Other diseases and conditions, significant laboratory or instrumental deviation, which, according to investigator opinion, may impact the results of the study, limit the patient's participation in the trial or create an unreasonable risk for the patient 9. Patient's unwillingness or disability to comply with the recommendations prescribed by protocol, as well as any concomitant medical or serious mental conditions that render the patient unsuitable for participation in the study, limit the legitimacy of obtaining informed consent or may affect the patient's ability to participate in the study (including disability to use a nebulizer) 10. Positive pregnancy test in women 11. The period of breastfeeding in women 12. Refusal of male patients and female patients with preserved reproductive function to use adequate methods of contraception throughout the study and for at least 30 days after the end of therapy with the studied drug