Fuzheng Yiliu-1010

Inclusion Criteria: 1. The age of the patients was 18-75 years old; 2. Radical resection of colorectal cancer (negative margin) was performed; 3. Patients with stage II high risk and stage III colorectal cancer confirmed by histology; 4. No liver, peritoneal or distant metastasis was found; 5. Patients with colorectal cancer who received standard chemotherapy or radiotherapy after operation and had no recurrence or metastasis at the end of radiotherapy and chemotherapy; 6. ECoG (Eastern Cooperative Oncology Group) score was 0-1; KPS score was 70 or above; 7. Liver function: SGOT and SGPT were less than 1.5 times of normal value, bilirubin was less than 1.5 mg / dl; 8. Renal function: creatinine \< 1.8mg/dl. Exclusion Criteria: 1. Allergic to the drug of this scheme; 2. Pregnant or lactating women with fertility requirements during the study period; 3. Severe hypertension, coronary heart disease, diabetes and so on, which are under control for half a year due to cardiovascular accident and poor drug control, are accompanied with other uncontrollable benign diseases such as lung, kidney, liver, infection, etc; 4. Participate in other studies before and during treatment; 5. There was a history of other malignant tumors or multi-source tumors within one year; 6. Chronic hepatitis B or C (high copy viral DNA) or activity in HIV infection history or active phase; 7. Patients with tuberculosis or seizures who need to be treated (e.g. steroids or antiepileptic therapy).