ACE and HLA Genotypes Predict Severity and Disease Progression in Danish Sarcoid Patients

N/ACompletedNCT04462068

University of Aarhus150 enrolled

Overview

Sarcoidosis is a multisystem granulomatous disease of unknown cause histologically characterized by noncaseating granulomas. Genetic factors affect disease course, which is highly variable and difficult to predict. This study aims to evaluate the predictive value of ACE and HLA genotypes on disease severity and progression in Danish patients with sarcoidosis.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Sarcoidosis

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosis of sarcoidosis * Signed informed consent Exclusion Criteria: * Inability or unwillingness to adhere to the study * Inability to give informed consent

Locations (1)

Aarhus University Hospital. Dep. of Respiatory Diseases and Allergology

Aarhus N, Denmark

Outcomes

Primary Outcomes

Time to initiation of treatment

Time to initiation of systemic immunosuppression for sarcoidosis

Time frame: 1 year from diagnosis

Secondary Outcomes

Number of participants with extrapulmonary organ involvement

Number of participants diagnosed with extrapulmonary organ involvement

Time frame: 1 year from diagnosis

Change in FEV1

Increase/ decline/ no change in FEV1

Time frame: 1 year

Change in FVC

Increase/ decline/ no change in FVC

Time frame: 1 year

Change in diffusion capacity

Increase/ decline/ no change in diffusion capacity

Time frame: 1 year

Data from ClinicalTrials.gov

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