Guided Cartilage Regeneration Membrane

Inclusion Criteria: 1. ≥18 years old and ≤50 years old, regardless of gender 2. 2 cm2 ≤ articular cartilage defect repair area ≤ 8 cm2, patients with feasible micro-fractures, no contraindications to surgery 3. Patients voluntarily participate in clinical trials, sign informed consent forms, and can cooperate with clinical follow-up Exclusion Criteria: 1. Those who have participated in clinical trials of other drugs or medical devices in the last 6 months 2. Those with stage III or above degeneration of bone and joint 3. Those who cannot accept pig-derived devices or have special religious beliefs due to religion, ethnicity and other issues 4. Those who are sensitive to collagen, foreign protein or pig-derived materials 5. Repair the damaged area\> 8 cm2 or \<2 cm2, lack of normal cartilage tissue around the injury 6. Severe heart, liver and kidney insufficiency are defined as: Heart function: NYHA grade III or above; ALT, AST\> 2.5 times the upper limit of normal value; Serum creatinine\> 1.5 times the upper limit of normal value; 7. People with systemic immune diseases or systemic or local infections 8. Joint fibrosis, joint stiffness, and obviously restricted movement 9. Those with moderate or severe osteoarthritis 10. People with contraindications for MRI examination 11. Patients with hemophilia 12. Those who cannot tolerate surgery 13. Women who are pregnant or plan to become pregnant and breastfeeding women 14. Persons with mental abnormalities and incapacity to act autonomously 15. Other conditions that the doctor judges cannot participate in the trial