The Absorption, Metabolism and Excretion of [14C]D-0316 in Human

Inclusion Criteria: * healthy male volunteers between the ages of 18 to 50 years old； * Body weight \>=50 kg, Body mass index (body weight(kg)/hight2(m2)) between 19 and 26 kg/m2； * Normal physical findings, clinical laboratory values, vital signs and 12-lead ECG, or any abnormality that is non-clinically significant; * Male subjects of reproductive potential with partners will be instructed to, and must be willing to practice a highly effective method of birth control for the duration of the study and continuing 1 year after discontinuing treatment with the investigational product. Highly effective methods of birth control include using condom, contraceptive sponge, contraceptive gel, contraceptive film, intrauterine device, oral or injectable contraceptive pill, hypodermic implants or others； * Must understand, and voluntarily sign the informed consent, comply with the requirements of the study. Exclusion Criteria: * History of or current clinically significant cardio, pulmonary, endocrine, metabolism, renal, hepatic, gastrointestinal, dermatology, infection, hematology, neurological, mental disease or disorder; * Positive test for HBsAg, HBeAg, anti-HCV, anti-HIV or syphilis antibody; * History of syncope / needle syncope and intolerable intravenous indwelling needle; * History of clinically significant disease or infection within 1 month before entering the study; * Abnormality in blood pressure, including hypertensive BP (SBP\>=140 mmHg, or DBP \>=90 mmHg), or hypotensive BP(SBP\<90 mmHg, or DBP \<=55 mmHg), Pulse rate\<55 bpm or \>100 bpm; * Long-QT syndrome or family history of it, or QTcB interval \> 450 ms; intraventricular blocks or left/right bundle branch block or QRS\>120ms; frequent ventricular ectopic beats (any 10s ECG ventricular premature beat \>= 1 in screening period); or abnormal resting heart rate (\> 100 bpm); * Received any drug within 14 days before taking the investigational drug, including any prescription drug, OTC drug, herbal drug or health care products, except for vitamins and paracetamol； * History of or current swallowing disorder, active gastrointestinal diseases, or other diseases that significantly affect absorption, distribution, metabolism and excretion of drugs; * Chronic constipation or diarrhea, irritable bowel syndrome, inflammatory bowel disease; * Hemorrhoids or perianal disease with regular/perianal bleeding; * Allergies, have allergies to two or more drugs or foods; or have known allergies to the components of the drug; * Participated in other clinical trials within 3 months before screening; * The subjects participated in the clinical trial of radioactive labeling within one year before taking the medicine; * Significant radiation exposure within one year prior to drug administration (more than one exposure from chest X-ray, CT scan, or barium meal examination and radiation-related occupations);