This study aims to identify and assess new CMR techniques that can improve current CMR protocols.
The aim of this study is to develop a comprehensive 10-minute protocol based on function and myocardial tissue characterization without the need for contrast injection, which can be standardized for 70% of cardiac patients. To test this 10-minute CMR protocol for its ability to significantly improve diagnostic decision-making and to reduce cost. To test its clinical feasibility, performance and cost-effectiveness in different populations including: Non-ischemic cardiomyopathies (-)OS-CMR and Ischemic Heart Disease and CAD (+)OS-CMR
Study Type
OBSERVATIONAL
Enrollment
2,130
McGill University Health Center
Montreal, Quebec, Canada
RECRUITINGPrimary diagnosis comparison between SMART CMR and standard CMR
(All patients) Agreement of the suggested primary diagnosis derived from SMART CMR, compared with the diagnosis established from standard CMR protocols, using the final clinical diagnosis as established by the treating physician, as a standard of truth. If the latter is not available, the conclusions based on the results of the standard CMR protocol will be used as the standard of truth.
Time frame: 2019-2025
Main finding comparison between SMART CMR and standard CMR in patients with suspected coronary artery disease
(Patients with suspected coronary artery disease:) Agreement of the main finding regarding the presence of a coronary territory at risk for inducible myocardial ischemia myocardial derived from OS-CMR, compared with standard first-pass perfusion CMR, using the coronary angiography report as a standard of truth. If the latter is not available, the conclusions based on the results of the standard CMR first pass perfusion scan will be used as the standard of truth.
Time frame: 2019-2025
SMART CMR scan completion percentage
Proportion of SMART CMR scans that could be completed according to the protocol
Time frame: 2019-2025
OS-CMR scan completion percentage
Proportion of OS-CMR scans that could be completed according to the protocol
Time frame: 2019-2025
Adverse event monitoring during SMART CMR sequences
Number and proportion of reported adverse events effects during SMART CMR
Time frame: 2019-2025
Adverse event monitoring during OS-CMR sequence
Number and proportion of reported adverse events during OS-CMR
Time frame: 2019-2025
SMART CMR sequence times vs standard protocol sequence times
Observed scan time for SMART CMR compared with the standard CMR protocol
Time frame: 2019-2025
OS-CMR sequence times vs standard protocol sequence times
Observed scan time for for OS-CMR during breathing maneuvers compared with the standard CMR first-pass perfusion protocol
Time frame: 2019-2025
Cost comparison of SMART CMR vs standard CMR protocol
Total estimated cost of SMART CMR compared with the standard CMR protocol
Time frame: 2019-2025
Cost comparison of OS-CMR vs standard CMR protocol
Total cost of OS-CMR with breathing maneuvers (based on scan time) vs the standard CMR first-pass perfusion protocol (calculated from the scan time plus any other material such as contrast agents or pharmacological vasodilators)
Time frame: 2019-2025
Septal myocardial T1 vs standard myocardial T1
Septal myocardial T1 as estimated from SMART CMR, compared with results from standard myocardial mapping
Time frame: 2019-2025
Septal myocardial T2 vs standard myocardial T2
Septal myocardial T2 as estimated from SMART CMR, compared with results from standard myocardial mapping
Time frame: 2019-2025
Quantitative parameter comparison between SMART CMR and CINE images
Quantitative parameters relevant to the diagnosis (see Appendix: CanSCMR Recommendations for reporting CMR) measured in SMART CMR images, compared with results from standard CMR cine images
Time frame: 2019-2025
Strain measurements vs standard cine image measurements
Longitudinal and circumferential strain measurements measured in SMART CMR images, compared with results from standard CMR cine images
Time frame: 2019-2025
SMART-CMR post-stenotic peak flow vs standard CMR flow images
Post-stenotic peak flow velocity in patients with suspected valvular disease measured in SMART CMR images, compared with results from standard CMR flow images
Time frame: 2019-2025
Intra- and inter-reader reproducibility
Correlation coefficients will be obtained to evaluate the intra- and inter-reader reproducibility of all quantitative markers.
Time frame: 2019-2025
Inter- and intra-scanner variability
Inter- and intra- scanner variability as assessed by ICC and kappa
Time frame: 2019-2025
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