A Study to Evaluate the Effect of Genetic Variation on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetics

Adrian Vella21 enrolled

Overview

The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

SalineOTHER

Saline will serve as the control

Exendin-9,39BIOLOGICAL

Exendin-9,39 will block the GLP-1 receptor

Eligibility

Sex: ALLMin age: 25 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 40 nondiabetic subjects will be recruited. * 20 subjects with the AA genotype at rs3765467 and remainder will have the GG genotype. * Individuals encompassing the age span of 25-65 years. Exclusion Criteria: * Individuals under 25 and over 65 years of age.

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States

Outcomes

Primary Outcomes

Insulin secretion quantified using the minimal model to generate an index of beta-cell responsivity (Φ)

Time frame: This will be calculated from the 0-180 minute data of the study

Secondary Outcomes

Glucagon secretion measured by immunoassay

Time frame: This will be averaged over the 0-180 minute data of the study

Data from ClinicalTrials.gov

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