A six month randomized controlled intervention with an exogenous ketone salt (EKS) supplement in mild cognitive impairment. Participants will receive 15 g of the supplement twice daily (equivalent to 24 g/day of EKS). Outcomes: brain energy metabolism, cognition, plasma biomarkers, brain imaging (volumetric, functional, structural) and quality of life will be analyzed before and after the intervention.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
65
2 x 12 g of EKS/day
Isocaloric placebo supplement with similar salt load but no EKS
Rearsh Centre on Aging
Sherbrooke, Quebec, Canada
Acetoacetate brain uptake
CMRacac measured by PET Scan
Time frame: 6 months
Glucose brain uptake
CMRgluc measured by PET Scan
Time frame: 6 months
Cognition
Time frame: 0-3-6-9 months
Plasma biomarkers
glucose, fatty acids, ketones
Time frame: 9 months
Structural and functional brain measures
Time frame: 6 months
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