Multiple-dose Tolerability and Pharmacokinetic of IBI362 in Chinese Patients With T2DM

\* Eligibility Criteria： Inclusion Criiteria: 1. Male or female 18 to 75 years of age at the time of consent. 2. T2D patients with poorly controlled blood glucose treated with lifestyle intervention or stable dose of metformin (≥ 1000mg/day or maximum tolerated dose) within 2 months prior to screening. 3. HbA1c 7.5% ≤ 11.0% by local laboratory at screening. 4. Body mass index 20 ≤ BMI ≤ 35 kg/m2. Exclusion Criteria: 1. Type 1 diabetes, special types of diabetes, or gestational diabetes. 2. Ketoacidosis or lactic acidosis within 6 months prior to screening. 3. History of severe hypoglycaemic episodes within 6 months prior to screening. 4. Acute myocardial infarction, unstable angina pectoris, coronary artery bypass grafting, coronary intervention (except diagnostic angiography), transient ischemic attack (TIA), cerebrovascular accident, acute and chronic heart failure within 6 months before screening. 5. Clinically symptomatic liver disease, acute or chronic hepatitis, or transaminases (ALT and AST) and alkaline phosphatase (ALP) \> 2 times the upper limit of normal and total bilirubin above the upper limit of normal at screening. 6. The patient was previously diagnosed with autonomic neuropathy, manifested as urinary retention, resting tachycardia, orthostatic hypotension and diabetic diarrhea.