The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials.
The investigators wish to better understand the role of the choriocapillaris (CC) in the formation and progression of non-exudative in age related macular degeneration (armd) by imaging the retinal pigment epithelium (rpe) and the choroidal microvasculature and by studying their inter-dependence to determine if the loss of the CC could prove useful as an anatomic clinical trial endpoint in future drug trials. This is an extension of a currently ongoing longitudinal observational study (BIRC-01) (NCT03688243).
Study Type
OBSERVATIONAL
Enrollment
450
All subjects will undergo retinal imaging using the Zeiss PlexElite SS-OCT, a non-contact, non-invasive ocular imaging instrument
University of California Los Angeles Doheny Eye Institute
Los Angeles, California, United States
RECRUITINGBascom Palmer Eye Institue
Miami, Florida, United States
RECRUITINGNew England Eye Center/Tufts Medical Center
Boston, Massachusetts, United States
Change in the Percentage of Choroidal Perfusion Deficits at 1 year compared to Baseline
Compare the percentage of choroidal perfusion deficits as measured using automated algorithms
Time frame: 1-year and 2-year time points
Pre-existing and new sub-clinical Macular Neovascularization (MNV)
Identify the number of abnormal new vessels arising from the Choroid at Baseline, 1-year and 2-year time points
Time frame: 1-year and 2-year time points
Automated Drusen Volume measurements
Compare the automated measurements of drusen volume using the Zeiss algorithm with manual measurements by trained readers
Time frame: 1-year and 2-year time points
Automated Geography Atrophy measurements
Compare the automated measurements of Geography Atrophy area using the Zeiss algorithm with manual measurements by trained readers
Time frame: 1-year and 2-year time points
Choroidal Thickness (millimeters)
Correlate Choroidal Thickness measurements (millimeters) with Age related Macular Degeneration (AMD) progression/Geographic Atrophy growth rates
Time frame: 1-year and 2-year time points
Choroidal Vascularity Index (percentage)
Correlate Choroidal Vascularity Index (percentage) with Age related Macular Degeneration (AMD) progression/Geographic Atrophy growth rates
Time frame: 1-year and 2-year time points
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Vitreous Retina Macular Consultants of NY
New York, New York, United States
RECRUITINGMelbourne University CERA
East Melbourne, Victoria, Australia
RECRUITING