Impact of Sinus Surgery on Individuals With Cystic Fibrosis

University of California, Los Angeles170 enrolled

Overview

This study will be a prospective, observational study of patients who undergo endoscopic sinus surgery for cystic fibrosis-related chronic rhinosinusitis (CRS). Individuals who do not undergo surgery but are treated medically for CRS will also be enrolled to serve as a control group. Outcomes analyzed will include pulmonary, quality of life, and others.

Study Type

OBSERVATIONAL

Enrollment

170

Conditions

Chronic Rhinosinusitis (Diagnosis)Cystic Fibrosis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Subjects between the ages of 18 years old (inclusive) and 99 years old (inclusive, subjects over the age of 89 will be recorded to be 89 years old). 2. Diagnosed with cystic fibrosis as established by genetic testing combined with clinical assessment and/or sweat chloride 3. Diagnosed with chronic rhinosinusitis by multidisciplinary sinusitis guidelines 4. chronic rhinosinusitis symptoms persisting beyond initial medical treatment 5. Counseled for endoscopic sinus surgery and ongoing medical therapy with each patient electing their preferred treatment Exclusion Criteria: 1. Underwent endoscopic sinus surgery in past 12 months 2. Will obtain follow up care at non-participating institutions 3. Unable to complete follow-up surveys

Locations (9)

University of California, Los Angeles

Los Angeles, California, United States

RECRUITING

Stanford University

Stanford, California, United States

RECRUITING

Outcomes

Primary Outcomes

Change in pulmonary function

Pulmonary function will be measured using spirometry - the percent of predicted forced expiratory volume in the first second (ppFEV1)