A Retrospective Cohort Study: Influence of MTHFR C677T and A1298C Polymorphisms on the Survival of Pediatric Patients With Non-Hodgkin's Lymphoma

Sun Yat-sen University374 enrolled

Overview

The primary purpose of this retrospective study was to investigate the influence of methylenetetrahydrofolate reductase (MTHFR) C677T/A1298C polymorphism on the survival of pediatric patients with Non-Hodgkin lymphoma (NHL) treated with modified NHL-BFM95 protocol in south China.

Study Type

OBSERVATIONAL

Enrollment

374

Conditions

Pediatric Non-Hodgkin Lymphoma

Eligibility

Sex: ALLMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. aged ≤ 18 years; 2. newly diagnosed as the four main categories of NHL(Burkitt's lymphoma, lymphoblastic lymphoma, anaplastic large cell lymphoma, and diffuse large B-cell lymphoma) between 2014 and 2020; 3. treated according to the modified BFM95 protocol. Exclusion Criteria: 1. aged \> 18 years; 2. not newly diagnosed as the four main categories of NHL between 2014 and 2020; 3. treated according to chemotherapeutic regimens except for the modified BFM95 protocol.

Locations (1)

Sun Yat-Sen University Cancer Center

Guangzhou, Guangdong, China

Outcomes

Primary Outcomes

Death

Overall survival time was calculated from the time of initial diagnosis to death

Time frame: About six years

Events including progression, relapse, and secondary cancer

Event-free survival (EFS) time was calculated from the time of initial diagnosis to first event.

Time frame: About six years

Data from ClinicalTrials.gov

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