Healthcare workers play a critical role in fighting the pandemic, not only by managing the patients' health clinically, but also by implementing adequate measures for infection prevention and control in healthcare facilities. This puts healthcare workers at a greater risk of acquiring the disease. COVID-19 is caused by Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) and many people can be infected with it asymptomatically and undetectably. Serology is an antibody test that provides additional information to polymerase chain-reaction (PCR) testing as it is the only way to reliably establish the fraction of the population that was infected . Seroconversion is the development of antibodies in the blood which can confirm suspected cases after the fact and reveal who was infected but asymptomatic and never realized it. Antibodies are specific proteins created as the body's response to the infection and this test is essential for detecting infected individuals with few or no symptoms at all.
Study Type
OBSERVATIONAL
Enrollment
1,200
Participants will be seen at T0 (baseline),T2 (2 months after T0), and T4 (2 months after T2). at every visit, participants will be asked to complete a general surveillance survey and a blood sample will be taken for the serology test.
Johns Hopkins Aramco Healthcare
Dhahran, Eastern Province, Saudi Arabia
Seroconversion status
Percentage of health care workers with positive serological markers to describe patterns in exposure, re-infection, clinical symptom, serological responses among health care workers based on their baseline serological status over a one year period.
Time frame: 6 Months
The proportion of asymptomatic infections among staff who have seroconverted
Seroconversion without clinical manifestation (fever, body aches, headache, sweating, chills + respiratory symptoms (cough dyspnea, sputum) or digestive (nausea / vomiting diarrhea abdominal pain)
Time frame: 6 Months
The durability of COVID 19 seroconversion in asymptomatic healthcare workers at JHAH
To identify the durability of antibody seroconversion
Time frame: 6 Months
Identification of risk factors for COVID 19 seroconversion in asymptomatic healthcare workers
Age, gender, type of staff, resources
Time frame: 6 Months
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