A Study of EDP-514 in Patients With Chronic Hepatitis B Virus Infection Who Are Not Currently on Treatment

Inclusion Criteria: * An informed consent document signed and dated by the subject. * Healthy male and female subjects of any ethnic origin between the ages of 18 and 70 years, inclusive * HBV DNA levels: * For subjects who are HBeAg positive at Screening, a Screening HBV DNA level in serum/plasma that is ≥20,000 IU/ml, or * For subjects who are HBeAg negative at Screening, a Screening HBV DNA level in serum/plasma that is ≥2,000 IU/mL, and * For all subjects, no HBV DNA serum/plasma test values \<1,000 IU/ml over the previous 12 months (using an approved test) * CHB subjects must not have been on prescribed anti-HBV treatment for at least 12 months prior to Screening Exclusion Criteria: * A documented prior diagnosis of cirrhosis * Pregnant or nursing females * Coinfection with human immunodeficiency virus (HIV), HCV, HDV, HAV, or HEV * Chronic liver disease of a non-HBV etiology; coexisting liver or biliary diseases