Thiol/Disulphide Homeostasis and Vascular Endothelial Growth Factor Levels in Diabetic Children

Aydin Adnan Menderes University80 enrolled

Overview

The aim of this study to evaluate the vascular endothelial growth factor level and thiol/disulphide homeostasis in saliva of diabetic children with gingivitis.

Eighty children (44 with type 1 diabetes mellitus and 44 systemically healthy) will be recruited for the study. The children will be divided into four subgroups based on their periodontal and systemic condition: 1) systemically and periodontally healthy children, 2) systemically healthy children with gingivitis, 3) periodontally healthy children with T1DM, and 4) children with T1DM and gingivitis. The plaque index, gingival index, probing pocket depth, will recorded. The vascular endothelial growth factor level determined by ELISA. Native thiol, total thiol and disulphide levels will be measured in saliva.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Periodontal Diseases

Interventions

ELISADIAGNOSTIC_TEST

Saliva sample collection

Eligibility

Sex: ALLMin age: 7 YearsMax age: 14 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Children diagnosed as type 1 diabetes mellitus * Age between 7-14 years Exclusion Criteria: * Having another systemic problem except type 1 diabetes mellitus * Children carrying orthodontic appliances

Locations (1)

Sultan Keles

Aydin, Turkey (Türkiye)

Outcomes

Primary Outcomes

Vascular endothelial growth factor level

Vascular endothelial growth factor level in saliva

Time frame: Baseline

Secondary Outcomes

Thiol/disulphide measurement

Total thiol, native thiol and disulphite level in saliva

Time frame: Baseline

Data from ClinicalTrials.gov

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