Comprehensive Genomic Profiling and Next Generation Functional Drug Screening for Patients With Aggressive Haematological Malignancies

Inclusion Criteria: * patient is suffering from aggressive haematological disease AND has undergone at least two lines of previous therapies AND/OR has undergone at least one previous therapy and no standard treatment is available in the specific disease setting and disease specific guidelines recommend treatment in studies. * duration of last response is less than 6 months defined as first day of last treatment to date of relapse, the response duration has to be available with dates (dd/mm/yyyy) for initiation of and relapse to previous treatment. * best response to previous treatment has to be available. * The patient is able to give written informed consent and wishes to undergo further therapy * further therapy is medically feasible * tumor cell-containing samples can be obtained Exclusion Criteria: * current participation in another experimental clinical trial * performance status does not allow participation (ECOG ˃ 1) * pregnancy, tested at screening * patient suffers from classical or nodular, lymphocyte predominant Hodgkins lymphoma. * other malignoma, diagnosed \<1a before inclusion (except localized squamous cell carcinoma of the skin, surgically curable melanoma of the skin, basal cell carcinoma of the skin)